The most common cow’s milk allergenic proteins regarding to allergic symptoms

Results Eighty six patients with CMA (3month to 18 yrs) were entered this study Fifty three patients were males (61.1%). Median of age was 2.5 yrs (Mean=3.98) and most of CMA patients was under 2 yrs (45.1 %). Mean of total IgE was 343.39±93.63 (SE)(0.2-5000IU/ml). The symptoms of patients was as following: (respiratory symptoms: 62.8%, Skin symptoms: 56.4%, gastrointestinal symptoms: 19.2% & Anaphylaxis: 13.6%). Totally, positive Specific IgE to cow’s milk protein, a-lactalbumin, casein, b-lactoglobulin and bovin serum albumin were 89.2%, 78.3%, 75%, 63.4%, & 45.5%, respectively. Although a-lactalbumin & casein were the most allergenic protein, mean of specific IgE concentration to blactoglobulin was highest in patients with CMA. There was a significant correlation between positive specific IgE to b-lactalbumin & anaphylaxis (P=0.05) and also between respiratory symptoms and positive specific IgE to casein (P=0.01). There was significant difference between mean of specific IgE to casein between males and females (P=0.001) that was the more frequent in males.